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SWIR imaging of Proimaging cancer tumor labeling dye CJ215

SWIR (short-wavelength infrared) imaging is emerging as a promising technique in medical imaging due to its distinct advantages. SWIR imaging captures and analyzes light in the wavelength range of approximately 900 to 1700 nanometers, providing valuable insights into tissue composition and pathology.

One key advantage of SWIR imaging is its ability to penetrate deeper into tissues compared to visible or near-infrared light. This allows for imaging of subsurface structures, making it valuable for applications such as cancer detection and diagnosis. By targeting specific molecular markers associated with cancer, SWIR imaging can provide high-resolution images, aiding in early detection, treatment planning, and monitoring of therapeutic response.

Additionally, SWIR imaging offers enhanced contrast and tissue transparency compared to other modalities. It is less affected by light scattering and absorption by water and blood, enabling clearer images even in the presence of biological tissues and bodily fluids. This property is particularly useful for visualizing blood vessels, assessing tissue perfusion, and monitoring wound healing.

SWIR imaging also holds potential for functional imaging and molecular diagnostics. By utilizing contrast agents that emit or absorb SWIR light, it becomes possible to visualize specific molecular markers, metabolic processes, and cellular functions within tissues. This enables a deeper understanding of diseases and may lead to personalized treatment approaches.

Moreover, SWIR imaging can be integrated into surgical procedures and endoscopy. It provides real-time visualization of tissue structures, blood vessels, and tumor margins, assisting surgeons in making precise decisions during interventions. It also holds promise for improving the detection and characterization of lesions during minimally invasive procedures.

CJ215 is a cancer tumor labeling dye that specifically binds to tumor tissues and allows visualization of cancer tumor delineation in fluorescence imaging. This NIR molecule can also be used in SWIR imaging.

Read more about CJ215 clinical development

Melanomes CJ215 NIR-II
Intravenous injection of CJ215 for melanoma targeting
Subcutaneous injection of CJ215 for lymphatic vessel visualization

Images acquired with NIR-II Kaer Imaging System (Kaer Labs) at IPBS – Toulouse

Product citations:

Poster: Novel fluorescent probes evaluated in an orthotopic pancreatic PDX model

Poster: CJ215, a new ultrasensitive near-infrared fluorescent probe for enhanced tumor detection in vivo

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