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HCQFluo AD538
Additional information
| Application | Nurr1 expression visualization |
|---|---|
| Max Absorption | 520 nm |
| Max Emission | 538 nm |
| Shipping condition | Room Temperature for up to 3 weeks |
| Storage condition | Store 12 months after receival under -15°C and protect from light |
| Molecular Weight | ∼ 760 |
| Solubility | – PBS Buffer (pH 7.4) + 1% Tween 80 |
HCQFluo AD538
Green Fluorescent Hydroxychloroquine
Ref: DJ407
725€
/1mg
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HCQFluo AD538 is a fluorescent conjugate molecule specifically designed to facilitate the study of Nurr1 expression through fluorescence microscopy.
Nurr1, part of the NR4A nuclear receptor family, plays a key role in the progression of Parkinson's disease (PD). Its gene expression is notably reduced in PD, making it a valuable therapeutic target in the search for new treatments. Activation of the Nurr1 receptor provides neuroprotective effects, including the reduction of inflammation, restoration of autophagy, and protection of neurons.
Hydroxychloroquine (HCQ), a specific marker of Nurr1, forms the basis of HCQFluo AD538, offering researchers a precise tool to advance therapeutic research in Parkinson's disease and other neurodegenerative conditions.
Product for Research Use Only. Not for Human Use.
Product citations :
An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models Nat Commun 14 , 4283 (2023). https://doi.org/10.1038/s41467-023-39970-9