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AACR 2020 – Novel fluorescent probes evaluated in an orthotopic pancreatic PDX model

Authors: Peggy Provent, Elodie Marie-Dit-Chatel, Jordan Longin, Stanislas Urbain, François Scherninski, Cyril Berthet 

Abstract: Fluorescent dyes have been used in medical diagnostics for over 50 years. The emergence of new fluorescent imaging technology in support of surgery and the need for increased sensitivity and precision have driven the search for novel fluorescent molecules. 

Orthotopic patient-derived xenograft (PDX) pancreatic tumor models provide a closely related human tumor within organ-specific tumor microenvironment, which was well suited to the evaluation of the tissue specificity of two novel fluorescent compounds, developed by Proimaging, with specific tumor uptake.

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Cellular tracers in fluorescence imaging are essential tools for studying various cellular processes, including cell migration, protein trafficking, organelle dynamics, and more...

A scratch assay is a widely used laboratory technique to study the ability of cells to migrate and close a "scratch" or "wound" made in a monolayer of cultured cells. This assay is valuable for studying cell migration, a fundamental process in tissue repair, development, and disease progression...

STED (stimulated emission depletion) microscopy offers several advantages over confocal microscopy: Higher resolution, improved contrast, faster imaging, multicolor imaging, reduced photobleaching and phototoxicity...

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