Phone
+33 (0)1 76 54 08 64
Address
66 avenue des Champs-Élysées
75008 Paris – France
WMIC 2018 – CJ215, a new ultrasensitive near-infrared fluorescent probe for enhanced tumor detection in vivo: a comparative study with ICG in a preclinical model
Authors: Valérie Rouffiac, Corinne Laplace-Builhé, Michel Urbain, Mélanie Polrot, François Scherninski
Abstract: The optimization of detection of subclinical lesions and intraoperative margins delineation is an important challenge in oncology to decrease the risk of local recurrence and preserve healthy tissue. For many years, clinical trials using near-infrared (NIR) optical imaging combined with ICG as contrast agent, try to address these issues. ICG is already approved for clinical use, but as a blood pool agent, it is not specific to tumor tissue. ICG shows a passive targeting based on enhanced permeability and retention effect, and thus is not ideally suited for image-guided surgery. In the present work, we assessed a new NIR fluorescent probe, the CJ215, in comparison with ICG, for tumor detection in a preclinical model of orthotopic mammary cancer.
Read more
LBL-Dye M580 is a photostable and no cytotoxic cellular tracer particularly well-adapted for long-time imaging on living or fixed cells…
A scratch assay is a widely used laboratory technique to study the ability of cells to migrate and close a “scratch” or “wound” made in a monolayer of cultured cells. This assay is valuable for studying cell migration, a fundamental process in tissue repair, development, and disease progression…
STED (stimulated emission depletion) microscopy offers several advantages over confocal microscopy: Higher resolution, improved contrast, faster imaging, multicolor imaging, reduced photobleaching and phototoxicity…
Proimaging